The Uchiha Clan were one of the founding noble families of Leaf village. The clan itself is said to be descended from the Hyuuga clan who possess the Byakugan bloodline and further back to be the heirs of the Rikudou Sennin's eldest son, who is said to have received his father's "eyes" and with it his powerful chakra and spiritual energy. Because their clan possessed the Sharingan or "Wheel Eye," the Uchiha excelled at being able to read and fend off attackers. This made them prime candidates to help found the Konoha Military Police Corps, which would incorporate the Uchiha fan symbol into their official logo.

Select few members of the Uchiha clan possess the ability to activate the bloodline Sharingan eye. This doujutsu (eye skill) gives one the ability to read Genjutsu, Taijutsu and Ninjutsu and then defeat it. As such, the clan member can view a technique being performed and see the tricks and movements required to be able to complete it. However the clan member can not copy techniques which are unique to another bloodline. It also gives one the ability to cast jutsu techniques only possible by possessing the eye such Amaterasu, Kamui, Susanoo and Tsukuyomi. The clan itself is known for their ties to fire. For a clan ninja to be seen as an adult, they must be able to utilize a Katon (Fire Element) jutsu such as Goukakyuu no Jutsu. Thus is the tie between the manipulation of fire and the mind of an Uchiha member.

The clan was founded by Uchiha Madara(Enzo) and his brother Izuna. In the early days of ninja battles, they battled the Senju Clan and eventually both groups came together to form Konoha. When Madara felt the clan was being marginalized by the Senju, he fought Konoha's Hokage and Senju clan leader Hashirama. Madara was defeated and went into hiding. Years later the clan began to become discontent with the village leadership and Madara returned. Before they could launch their insurrection against Konoha, they were wiped out by one of their own, Uchiha Itachi. Only one member from within the clan was spared, Itachi's brother Sasuke. Itachi and later Sasuke would join Madara in his drive to plunge the world into darkness, for their own ends. With Itachi's death as a man willing to sacrifice everything to secretly support Konoha, the final fate of the clan and its future thus rests in the hands of men swearing vengence against their home village.