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You can just not the brain, you get a disease from ingesting prions that is a enzyme in the brain.
Edit: They aren't enzymes sorry they are infectious proteins and are resistant to enzymes if i am remembering correctly they cause abnormal folding of normal proteins causing neurodegenerative diseases
if they can't do that, well
all kinds of stuff might happen,
including but not limited to holding as much as they can, eating the animals, each other,
surrender to the attacker or even perform a heroic 'exodus' that might be suicide.
Cannibalism
Suicide attack
And in some case just hold out until invaders run out of food.
But usually cities back then have some means of producing food within its border so they can hold out for years or indefinitely unless other tactics are used.
There are many examples in history.
https://www.youtube.com/watch?v=IIiIkjcImzA
they ate around 20000 to 30000 people in that siege. crazy.
Risk of infectious prion diseases
The most severe and definitive risk of cannibalism is contracting a transmissible spongiform encephalopathy (TSE), which is an incurable, fatal, neurodegenerative disease. These are caused by prions, which are abnormally folded proteins that cause normal proteins in the brain to also misfold.
Kuru: An epidemic of this disease occurred among the Fore people of Papua New Guinea due to their ritualistic practice of consuming the brains of deceased relatives.
Cause: Kuru is caused by prions found in human brain tissue. Women and children, who traditionally ate the brains, were the most affected.
Symptoms: These include muscle jerks, coordination problems, emotional instability, and dementia. It is also called "the laughing sickness" due to pathological bursts of laughter.
Outcome: The disease has a long incubation period, but once symptoms appear, death usually occurs within one to two years.
Insusceptible to cooking: Prions are not destroyed by cooking, so infected human tissue cannot be made safe by applying heat.
Other health risks
Beyond prions, cannibalism exposes a person to other dangerous pathogens.
Blood-borne diseases: Eating human flesh or coming into contact with a corpse's blood can transmit blood-borne diseases like hepatitis, Ebola, and HIV.
Bacterial and parasitic infections: Poorly handled human flesh can lead to bacterial contamination, including from E. coli or other gut pathogens.
Concentrated hormones and toxins: Certain human organs contain high concentrations of hormones that can disrupt your body's systems. This is a common reason for avoiding certain organs when consuming animal flesh, and the risk is even higher with a closely related species like humans.
Limited nutritional value
Even without the risk of disease, human flesh is not a highly nutritious food source, especially when compared to wild game. A 2017 study found that human bodies offer significantly less caloric value than other animals that were hunted by Paleolithic humans. In a dire survival situation, the energy gained would be minimal compared to the extreme risks involved.
again prions are inhumane
https://www.justsecurity.org/29157/siege-warfare-starvation-civilians-war-crime/
https://en.wikipedia.org/wiki/Siege_of_Leningrad#Background
For example when the French attempted to starve out the English army in 1415. The English moved their camp slightly forward to hit the French army with their longbowmen and crazy enough even won the battle.