Guess you're left handed? Movement via keyboard ought to be bound to WASD, but it can be altered in the Settings>Controls>Keyboard and Mouse>move.
The game will ask for which keys you want to use if you click on 'move'.

WASD stopped working for me after completing the Wendy chapter and before starting Frank. Was working fine for 19 hours of play before then. Even Settings>Controls?Keyboard and Mouse>move works (setting WASD); but when the game starts, WASD doesn't work. I switched over to Homesick game and WASD works fine there.

Originally posted by chantal.penrose:

my mouse (both buttons but scroll wheel), moving with the arrows and hit random buttons to see what happens. No luck, I can only turn my head and look up and down but not actually move in any direction. Any advice?

Do you have a controller plugged in as well? Try unplugging it...

I just downloaded the game, I can move around just fine (keyboard & mouse) but every time after an ORB scene I cannot move left or right. I have to save, exit the game, re-enter to get my full movement again. Is there a patch?