Not in the game itself, but you can tweak the scenario/save files. In the game, you can turn off "random events," which will disable plagues but also revolts.

If you want to modify the files, you'll need to open your save/scenario .ims file in a text editor and change the probability values. Since different difficulty levels have different values, follow these steps:

1. Find the "PlagueExtendedMoveEvent" MoveEvent and change the probability to "0.0".
   
2. Locate all lines with <MoveEventsDifficultySetting id="1"> and, within each, find the DifficultySettingVariable with the name "probability" and set its value to "0.0". Since there are multiple difficulty levels, you will need to update each occurrence.

This will effectively disable any chance of a plague occurring. It should work for both save files and scenario files, though I can only guarantee a 100% smooth experience for scenario files. Save files may already have variables tied to events, which, in very specific cases, could cause incompatibilities.

one question though is that also blocks revolts right, since id 4 appears to mention revolt in the name;

I think Pavel misread your ask (i.e. deactivate revolts while keeping plagues). Plagues should be id="1".

Is it possible to prevent the plague from moving? (like 0 probability).I like the plague mechaninc, but i want to be a local event, instead of global pandemic that killls millions of people.

Also @kaysoky, he did said on the answer

This will effectively disable any chance of a plague occurring. It should work for both save files and scenario files,

Kaysoky is absolutely right (thank you Kaysoky) — I somehow mixed up plague and revolt.

You should look for PlagueExtendedMoveEvent and the corresponding <MoveEventsDifficultySetting id="1"> in the files.

To avoid any confusion, I’ve also updated my original answer so other players searching for the same information will find the correct details.

Originally posted by Henrique Lique:

Is it possible to prevent the plague from moving? (like 0 probability)

You could set "speedOfSpreading" to an effectively zero value (like 0.001), which would technically stop the plague from spreading. However, this wouldn’t make much sense—it would simply appear in one or two towns without affecting anything else.

It sounds like you might prefer the original plague mechanic from the vanilla game, where the plague was a one-turn event with no spreading at all.

still trying to find a good balance. I actually like current plague systems, and even went to read about, but only 4 huge plagues (like the one's it happens on the game) on 800 hundreds years (talking about ancient times).

Had a game on age alexander where it happened 3 times, in around 150 turns. (around 12 years). i'll prob just reduce speed of spreading and mortality to make it more realistically (since we can't put random factor on the strenght of the plague).

thanks for pointing out files.

I'm here to chime in that I find the plague mechanic completely absurd.

In the space of 2 turns 15 cities got hit. And better still I got, and yes I went and counted them up because it annoyed the hell out of me, 31 notifications about the plague at the beginning of the turn.